Perspectives On Animal Research
Volume 1, Supplement
An Evaluation of Ten Randomly-Chosen Animal Models
of Human Disease
Stephen R. Kaufman, M.D.
Brandon P. Reines, D.V.M.
Holly Casele, BA
Lydia Lawson, BA.
Jon Lurie, B.S.E.
Medical Research Modernization Committee
Published by
Medical Research Modernization Committee
Copywrite: 1989 Medical Research Modernization Committee
Republished with permission
Originally Printed in the Unites States of America
Library of Congress National Serials Data Program
International Standard Serial Number 1045-0424
ISBN 0-9623858-2-4
ISBN 0-9623858-3-2 (pbk)
Acknowledgements:
We would like to thank the Physician's Committee for Responsible Medicine for sponsoring the summer fellowship program, which made this research possible. We would also like to thank John McArdle, Ph.D., Neal Barnard, M.D., Martin Stephens, Ph.D., and Murry Cohen, M.D. for their helpful review of the manuscript.
Table of Contents
1. Model No. 4: Bacterial Endocarditis
(Opossum)
2. Model No. 38: Vitamin A
Deficiency Hydrocephaly (Rabbit)
3. Model No. 42: Adenocarcinoma
(Rat)
4. Model No. 114: Osteosarcoma
(Rat)
5. Model No. 149: Giardiasis (Mouse)
6. Model No. 157: Congenital
Hyperbilirubinemia (Rat)
7. Model No. 196: Anti-Tubular-Basement-Membrane-Antibody
Tubulo-interstitial Nephritis (Guinea Pig)
8. Model No. 234: Benign
Monoclonal Gammopathy (Mouse)
9. Model No. 176: Globoid
Cell Leukodystrophy (Mouse)
10. Model No. 319: Large Granular
Lymphocytic Leukemia (Rat)
Appendix A: Citations
Appendix B: Random
Number Program
Appendix C: Researchers' Comments and Replies